Name: Ccl6 Antibody (PACO17661)
SKU: PACO17661
Availability: OutOfStock

Antibody Name:	Ccl6 Antibody (PACO17661)
Antibody SKU:	PACO17661
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:10000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of mouse Ccl6

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17661(Ccl6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, and can be greatly induced under conditions suitable for myeloid cell differentiation. It is highly expressed in bone marrow cultures that have been stimulated with the cytokine GM-CSF. Some low levels of gene expression also occur in certain cell lines of myeloid origin (e.g. the immature myeloid cell lines DA3 and 32D cl3, and the macrophage cell line P388D) that can also be greatly induced in culture with GM-CSF. However, in activated T cell lines, expression of CCL6 is greatly reduced.CCL6 can also be induced in the mouse lung by the cytokine interleukin 13

Synonyms:

chemokine (C-C motif) ligand 6

UniProt Protein Function:	CCL6: Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:chemokine activity; cytokine activity Biological Process: immune response; chemotaxis
UniProt Code:	P27784
NCBI GenInfo Identifier:	115197
NCBI Gene ID:	20305
NCBI Accession:	P27784.1
UniProt Secondary Accession:	P27784,Q3U3W3, Q5QNW1, Q99M24, Q9D830,
UniProt Related Accession:	P27784
Molecular Weight:	12,984 Da
NCBI Full Name:	C-C motif chemokine 6
NCBI Synonym Full Names:	chemokine (C-C motif) ligand 6
NCBI Official Symbol:	Ccl6
NCBI Official Synonym Symbols:	c10; MRP-1; Scya6
NCBI Protein Information:	C-C motif chemokine 6; CC chemokine C10; small inducible cytokine A6; small-inducible cytokine A6
UniProt Protein Name:	C-C motif chemokine 6
UniProt Synonym Protein Names:	Protein C10; Small-inducible cytokine A6Cleaved into the following 2 chains:CCL6(22-95); CCL6(23-95)
Protein Family:	Para-Rep
UniProt Gene Name:	Ccl6
UniProt Entry Name:	CCL6_MOUSE