Ccl4 Antibody (PACO32656)
- SKU:
- PACO32656
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Ccl4 Antibody (PACO32656) |
| Antibody SKU: | PACO32656 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse C-C motif chemokine 4 protein (24-92AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO32656 at dilution of 1:100. |
| Background: | Monokine with inflammatory and chemokinetic properties. |
| Synonyms: | C-C motif chemokine 4 (Immune activation protein 2) (ACT-2) (ACT2) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4), Ccl4, Mip1b Scya4 |
| UniProt Protein Function: | CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding Biological Process: leukocyte chemotaxis; response to toxin; immune response; positive regulation of calcium-mediated signaling; positive regulation of tumor necrosis factor production; inflammatory response; chemotaxis; positive regulation of calcium ion transport; positive regulation of vascular permeability |
| UniProt Code: | P14097 |
| NCBI GenInfo Identifier: | 1346534 |
| NCBI Gene ID: | 20303 |
| NCBI Accession: | P14097.3 |
| UniProt Related Accession: | P14097 |
| Molecular Weight: | 10,168 Da |
| NCBI Full Name: | C-C motif chemokine 4 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 4 |
| NCBI Official Symbol: | Ccl4 |
| NCBI Official Synonym Symbols: | Act-2; Mip1b; Scya4; MIP-1B; AT744.1 |
| NCBI Protein Information: | C-C motif chemokine 4; ACT2; SIS-gamma; MIP-1 beta; MIP-1-beta; immune activation protein 2; small inducible cytokine A4; small-inducible cytokine A4; macrophage inflammatory protein 1-beta |
| UniProt Protein Name: | C-C motif chemokine 4 |
| UniProt Synonym Protein Names: | Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | Ccl4 |
| UniProt Entry Name: | CCL4_MOUSE |
| ELISA Kits |
| Mouse MIP-1b / MIP-1 beta ELISA Kit |
| Mouse MIP-1 beta (Macrophage Inflammatory Protein 1 Beta)CLIA Kit (MOES00008) |
| Mouse C-C motif chemokine 4 (Ccl4) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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