Description
Antibody Name: | CCDC8 Antibody (PACO47138) |
Antibody SKU: | PACO47138 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IF:1:50-1:200 |
Species Reactivity: | Human, Mouse |
Immunogen: | Recombinant Human Coiled-coil domain-containing protein 8 protein (214-513AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunofluorescent analysis of Hela cells using PACO47138 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Western Blot. Positive WB detected in: Mouse liver tissue. All lanes: CCDC8 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 60 kDa. Observed band size: 60 kDa. |
Background: | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome. |
Synonyms: | Coiled-coil domain-containing protein 8, CCDC8 |
UniProt Protein Function: | CCDC8: Defects in CCDC8 are the cause of 3M syndrome type 3 (3M3). A disorder characterized by poor postnatal growth and distinctive facial features, including triangular facies, frontal bossing, fleshy tipped nose, and fleshy lips. Other features may include skeletal anomalies and prominent heels.Protein type: Unknown functionChromosomal Location of Human Ortholog: 19q13.32Cellular Component: centrosome; cytoplasm; plasma membraneBiological Process: regulation of mitosis; microtubule cytoskeleton organization and biogenesisDisease: Three M Syndrome 3 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9H0W5 |
NCBI GenInfo Identifier: | 199559779 |
NCBI Gene ID: | 83987 |
NCBI Accession: | NP_114429.2 |
UniProt Secondary Accession: | Q9H0W5,Q8TB26 |
UniProt Related Accession: | Q9H0W5 |
Molecular Weight: | 59,374 Da |
NCBI Full Name: | coiled-coil domain-containing protein 8 |
NCBI Synonym Full Names: | coiled-coil domain containing 8 |
NCBI Official Symbol: | CCDC8 |
NCBI Official Synonym Symbols: | 3M3; p90; PPP1R20 |
NCBI Protein Information: | coiled-coil domain-containing protein 8; protein phosphatase 1, regulatory subunit 20 |
UniProt Protein Name: | Coiled-coil domain-containing protein 8 |
UniProt Synonym Protein Names: | |
Protein Family: | Coiled-coil domain-containing protein |
UniProt Gene Name: | CCDC8 |
UniProt Entry Name: | CCDC8_HUMAN |