CCDC28B Antibody (PACO61177)
- SKU:
- PACO61177
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CCDC28B Antibody (PACO61177) |
| Antibody SKU: | PACO61177 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Coiled-coil domain-containing protein 28B protein (1-76AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61177 diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. |
| Synonyms: | Coiled-coil domain-containing protein 28B, CCDC28B |
| UniProt Protein Function: | CCDC28B: Involved in ciliogenesis. Interacts with BBS1, BBS2, BBS4, BBS5, BBS6, BBS7 AND BBS8Chromosomal Location of Human Ortholog: 1p36.11-p34.2Cellular Component: centrosome; cytoplasmMolecular Function: protein bindingBiological Process: cilium biogenesisDisease: Bardet-biedl Syndrome 1 |
| UniProt Protein Details: | |
| NCBI Summary: | The product of this gene localizes to centrosomes and basal bodies. The protein colocalizes with several proteins associated with Bardet-Biedl syndrome (BBS) and participates in the regulation of cilia development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q9BUN5 |
| NCBI GenInfo Identifier: | 666335631 |
| NCBI Gene ID: | 79140 |
| NCBI Accession: | NP_001287940.1 |
| UniProt Secondary Accession: | Q9BUN5,Q8TBV8, A8K789 |
| UniProt Related Accession: | Q9BUN5 |
| Molecular Weight: | 26,904 Da |
| NCBI Full Name: | coiled-coil domain-containing protein 28B isoform 1 |
| NCBI Synonym Full Names: | coiled-coil domain containing 28B |
| NCBI Official Symbol: | CCDC28B |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | coiled-coil domain-containing protein 28B |
| UniProt Protein Name: | Coiled-coil domain-containing protein 28B |
| UniProt Synonym Protein Names: | |
| Protein Family: | Coiled-coil domain-containing protein |
| UniProt Gene Name: | CCDC28B |
| UniProt Entry Name: | CC28B_HUMAN |
| Antibodies |
| CCDC28B Antibody (PACO08227) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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