CCDC106 Antibody (PACO15943)
- SKU:
- PACO15943
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CCDC106 Antibody (PACO15943) |
| Antibody SKU: | PACO15943 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human CCDC106 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15943(CCDC106 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15943(CCDC106 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53. |
| Synonyms: | coiled-coil domain containing 106 |
| UniProt Protein Function: | CCDC106: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleusMolecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BWC9 |
| NCBI GenInfo Identifier: | 94536856 |
| NCBI Gene ID: | 29903 |
| NCBI Accession: | NP_037433.2 |
| UniProt Secondary Accession: | Q9BWC9,Q99786, B3KUF9, D3K183 |
| UniProt Related Accession: | Q9BWC9 |
| Molecular Weight: | 32,032 Da |
| NCBI Full Name: | coiled-coil domain-containing protein 106 |
| NCBI Synonym Full Names: | coiled-coil domain containing 106 |
| NCBI Official Symbol: | CCDC106 |
| NCBI Official Synonym Symbols: | ZNF581; HSU79303 |
| NCBI Protein Information: | coiled-coil domain-containing protein 106; protein predicted by clone 23882 |
| UniProt Protein Name: | Coiled-coil domain-containing protein 106 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | CCDC106 |
| UniProt Entry Name: | CC106_HUMAN |
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