CBY1 Antibody, FITC conjugated (PACO64089)

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SKU:
PACO64089

Description

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Antibody Name:CBY1 Antibody?FITC conjugated (PACO64089)
Antibody SKU:PACO64089
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Recombinant Human Protein chibby homolog 1 protein (41-126AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Antigen Affinity purified & Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:FITC
Background:Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
Synonyms:Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1), CBY1, ARB1 C22orf2 CBY PGEA1
UniProt Protein Function:CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 22q12Cellular Component: cytosol; nucleoplasm; nucleus; trans-Golgi networkMolecular Function: beta-catenin binding; identical protein binding; protein bindingBiological Process: cardiac muscle cell differentiation; fat cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; protein localization
UniProt Protein Details:
NCBI Summary:Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y3M2
NCBI GenInfo Identifier:20454882
NCBI Gene ID:25776
NCBI Accession:Q9Y3M2.1
UniProt Secondary Accession:Q9Y3M2,Q66GT6, Q9UIK9, B2R4S2
UniProt Related Accession:Q9Y3M2
Molecular Weight:14,470 Da
NCBI Full Name:Protein chibby homolog 1
NCBI Synonym Full Names:chibby family member 1, beta catenin antagonist
NCBI Official Symbol:CBY1  
NCBI Official Synonym Symbols:CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A  
NCBI Protein Information:protein chibby homolog 1
UniProt Protein Name:Protein chibby homolog 1
UniProt Synonym Protein Names:ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
Protein Family:Protein chibby
UniProt Gene Name:CBY1  
UniProt Entry Name:CBY1_HUMAN
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
FITC
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