Cavia porcellus CTLA-4/CD152 Recombinant Protein (RPES4219)

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SKU:
RPES4219
Product Type:
Recombinant Protein
Species:
Guinea pig

Description

system_update_altDatasheet

Cavia porcellus CTLA-4/CD152 Recombinant Protein

Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

Product Name:Cavia porcellus CTLA-4/CD152 Recombinant Protein (RPES4219)
Product Code:RPES4219
Size:10µg
Species:Cavia porcellus
Expressed Host:P.Pichia
Synonyms:Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4
Accession:H0VUB1
Sequence:Ala37-Asp161
Fusion tag:C-His
Activity:Immobilized Mouse B7-1-Fc(Cat: PKSM041366) at 1µg/ml(100 ?l/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Cavia porcellus CTLA-4-His is 0.17ug/ml .
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Cavia porcellus CD152 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus.
Purity:> 90% as determined by reducing SDS-PAGE.
Mol Mass:14.1 kDa
AP Mol Mass:18-40 kDa
Formulation:Supplied as a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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