CATSPER4 Antibody (PACO36806)
- SKU:
- PACO36806
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CATSPER4 Antibody (PACO36806) |
| Antibody SKU: | PACO36806 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cation channel sperm-associated protein 4 protein (306-472AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of Hela cells using PACO36806 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO36806 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO36806 at dilution of 1:100. |
| Background: | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-α = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. |
| Synonyms: | Cation channel sperm-associated protein 4 (CatSper4), CATSPER4 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7RTX7 |
| NCBI GenInfo Identifier: | 62988334 |
| NCBI Gene ID: | 378807 |
| NCBI Accession: | NP_937770.1 |
| UniProt Secondary Accession: | Q7RTX7 |
| UniProt Related Accession: | Q7RTX7 |
| Molecular Weight: | |
| NCBI Full Name: | cation channel sperm-associated protein 4 |
| NCBI Synonym Full Names: | cation channel sperm associated 4 |
| NCBI Official Symbol: | CATSPER4 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cation channel sperm-associated protein 4 |
| UniProt Protein Name: | Cation channel sperm-associated protein 4 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | CATSPER4 |
| UniProt Entry Name: | CTSR4_HUMAN |
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