CASTOR2 Antibody (PACO63407)
- SKU:
- PACO63407
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CASTOR2 Antibody (PACO63407) |
| Antibody SKU: | PACO63407 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate. All lanes: CASTOR2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 37 kDa. Observed band size: 37 kDa. |
| Background: | Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
| Synonyms: | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2), CASTOR2, GATSL1 GATSL2 |
| UniProt Protein Function: | GATSL2: Belongs to the GATS family.Chromosomal Location of Human Ortholog: 7q11.23 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | A6NHX0 |
| NCBI GenInfo Identifier: | 222831645 |
| NCBI Gene ID: | 729438 |
| NCBI Accession: | NP_001138536.1 |
| UniProt Secondary Accession: | A6NHX0,B9EJH9 |
| UniProt Related Accession: | A6NHX0, A6NNH0 |
| Molecular Weight: | 36,056 Da |
| NCBI Full Name: | GATS-like protein 2 |
| NCBI Synonym Full Names: | GATS protein-like 2 |
| NCBI Official Symbol: | GATSL2 |
| NCBI Official Synonym Symbols: | GATSL1 |
| NCBI Protein Information: | GATS-like protein 2 |
| UniProt Protein Name: | GATS-like protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | GATS-like protein |
| UniProt Gene Name: | GATSL2 |
| UniProt Entry Name: | GATL2_HUMAN |
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