Caspase-9 Polyclonal Antibody
- SKU:
- CAB21682
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Caspase-9 Polyclonal Antibody |
| Product Code: | CAB21682 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, HepG2 |
| Cellular Location: | apoptosome, cytoplasm, cytosol, mitochondrion, nucleus |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 139-416 of Caspase-9 (NP_001220.2). |
| Sequence: | VGALE SLRGN ADLAY ILSME PCGHC LIINN VNFCR ESGLR TRTGS NIDCE KLRRR FSSLH FMVEV KGDLT AKKMV LALLE LAQQD HGALD CCVVV ILSHG CQASH LQFPG AVYGT DGCPV SVEKI VNIFN GTSCP SLGGK PKLFF IQACG GEQKD HGFEV ASTSP EDESP GSNPE PDATP FQEGL RTFDQ LDAIS SLPTP SDIFV SYSTF PGFVS WRDPK SGSWY VETLD DIFEQ WAHSE DLQSL LLRVA NAVSV KGIYK QMPGC FNFLR KKLFF KTS |
| Synonyms: | MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6 |
| Calculated MW: | 46kDa |
| Observed MW: | 45kDa |
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