Description
Product Name: | Caspase-6 Monoclonal Antibody |
Product Code: | CAB22437 |
Reactivity: | Mouse, Rat |
Applications: | Immunohistochemistry |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC2627 |
Reactivity: | Mouse, Rat |
Tested Applications: | IHC-P, ELISA |
Key Applications: | Immunohistochemistry |
Recommended Dilution: | IHC-P 1:50-1:200 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Cellular Location: | Cytoplasm |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms.
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human Caspase-6 (P55212). |
Sequence: | SLVGK PKIFI IQACR GNQHD VPVIP LDVVD NQTEK LDTNI TEVDA ASVYT LPAGA DFLMC YSVAE GYYSH RETVN GSWYI QDLCE MLGKY GSSLE FTELL T |
Synonyms: | MCH2, CSP-6, caspase-6 |
Calculated MW: | 33kDa |
Observed MW: | Refer to figures |