Caspase-3 p17 Polyclonal Antibody
- SKU:
- CAB21677
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | Caspase-3 p17 Polyclonal Antibody |
| Product Code: | CAB21677 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, Jurkat, Mouse lung |
| Cellular Location: | Cytoplasm |
| Customer Validation: | WB(Homo sapiens) |
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-175 of human Caspase-3 (NP_004337.2). |
| Sequence: | SGISL DNSYK MDYPE MGLCI IINNK NFHKS TGMTS RSGTD VDAAN LRETF RNLKY EVRNK NDLTR EEIVE LMRDV SKEDH SKRSS FVCVL LSHGE EGIIF GTNGP VDLKK ITNFF RGDRC RSLTG KPKLF IIQAC RGTEL DCGIE TD |
| Synonyms: | CPP32, SCA-1, CPP32B |
| Calculated MW: | 32kDa |
| Observed MW: | 32kDa/17kDa |
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