Caspase-1 Polyclonal Antibody
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- SKU:
- CAB21296
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
- Applications:
- IF
_IHC_01__31356__57453.1706546971.jpg?c=1&imbypass=on "Caspase-1 Polyclonal Antibody")
Description
| Product Name: | Caspase-1 Polyclonal Antibody |
| Product Code: | CAB21296 |
| Reactivity: | Human, Mouse |
| Applications: | Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | IHC-P, IF/ICC, ELISA |
| Key Applications: | Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm |
| Customer Validation: | WB(Mus musculus, Rattus norvegicus)IHC(Homo sapiens) |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 198-297 of human Caspase-1 (NP_150634.1). |
| Sequence: | YSVDV KKNLT ASDMT TELEA FAHRP EHKTS DSTFL VFMSH GIREG ICGKK HSEQV PDILQ LNAIF NMLNT KNCPS LKDKP KVIII QACRG DSPGV VWFKD |
| Synonyms: | ICE, P45, IL1BC |
| Calculated MW: | 45kDa |
| Observed MW: | Refer to figures |
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