CARF Antibody (PACO15413)
- SKU:
- PACO15413
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CARF Antibody (PACO15413) |
| Antibody SKU: | PACO15413 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human CARF |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, K562 cells, Primary antibody: PACO15413(CARF Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
| Background: | CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid, nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell. |
| Synonyms: | calcium responsive transcription factor |
| UniProt Protein Function: | CARF: May be a transcription factor. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factorChromosomal Location of Human Ortholog: 2q33.2Cellular Component: nucleusMolecular Function: DNA binding; transcription factor activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N187 |
| NCBI GenInfo Identifier: | 85540610 |
| NCBI Gene ID: | 79800 |
| NCBI Accession: | Q8N187.2 |
| UniProt Secondary Accession: | Q8N187,Q8ND29, Q8WXC0, Q96J78, Q96Q38, Q96Q39, Q9H712 B4E1W7, G3V1K7 |
| UniProt Related Accession: | Q8N187 |
| Molecular Weight: | 72,385 Da |
| NCBI Full Name: | Calcium-responsive transcription factor |
| NCBI Synonym Full Names: | calcium responsive transcription factor |
| NCBI Official Symbol: | CARF |
| NCBI Official Synonym Symbols: | ALS2CR8; NYD-SP24 |
| NCBI Protein Information: | calcium-responsive transcription factor |
| UniProt Protein Name: | Calcium-responsive transcription factor |
| UniProt Synonym Protein Names: | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; Calcium-response factor; CaRF; Testis development protein NYD-SP24 |
| Protein Family: | Calcium-responsive transcription factor |
| UniProt Gene Name: | CARF |
| UniProt Entry Name: | CARTF_HUMAN |
| Antibodies |
| CARF Antibody (PACO00389) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
