Cardiac Troponin I (TNNI3) Monoclonal Antibody (CAB22387)
- SKU:
- CAB22387
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | Cardiac Troponin I (TNNI3) Monoclonal Antibody |
| Product Code: | CAB22387 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC5109-09 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:10000-1:30000, IF/ICC 1:200-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse heart |
| Cellular Location: | cardiac myofibril, cytosol, sarcomere |
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
| Immunogen: | Recombinant protein of human Cardiac Troponin I (TNNI3). |
| Sequence: | Email for sequence |
| Synonyms: | CMH7, RCM1, cTnI, CMD2A, TNNC1, CMD1FF |
| Calculated MW: | 24kDa |
| Observed MW: | 28kDa |
Related Products
Cardiac Troponin I (TNNI3) Monoclonal Antibody (CAB21251)
Cardiac Troponin I (TNNI3) Monoclonal Antibody (CAB21246)
Cardiac Troponin I (TNNI3) Monoclonal Antibody (CAB21247)
Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody
