Canine IL-2 Recombinant Protein (RPPB0491)
- SKU:
- RPPB0491
- Product Type:
- Recombinant Protein
- Species:
- Canine
- Uniprot:
- Q29416
Description
| Product Name: | Canine IL-2 Recombinant Protein |
| Product Code: | RPPB0491 |
| Size: | 100µg |
| Species: | Canine |
| Target: | IL-2 |
| Synonyms: | Interleukin-2, IL-2, T-cell growth factor, TCGF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a sterile (0.2�m) filtered solution containing 20 mM sodium bicarbonate, pH 8.5. |
| Solubility: | It is recommended to reconstitute the lyophilized IL-2 in Sterile 10 mM sodium bicarbonate, pH 8.5 at 0.1 mg/mL, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-2 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAPITSSSTK ETEQQMEQLL LDLQLLLNGV NNYENPQLSR MLTFKFYTPK KATEFTHLQC LAEELKNLEE VLGLPQSKNV HLTDTKELIS NMNVTLLKLK GSETSYNCEY DDETATITEF LNKWITFSQS IFSTLT |
| Biological Activity: | The ED50, as determined by CTLL-2 cell proliferation is <5ng/ml corresponding to a specific activity which is ? 2.0 x 10^5 units/mg. |
IL2 is a secreted cytokine that is essential for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 and interleukin 7. The expression of IL2in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the exact expression of a single gene.
Interleukin-2 Canine Recombinant produced in E. coli is a non-glycosylated monomer chain containing 136 amino acids and having a molecular mass of 15.6kDa.IL-2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. |
| UniProt Code: | Q29416 |
| NCBI GenInfo Identifier: | 3024011 |
| NCBI Gene ID: | 403989 |
| NCBI Accession: | Q29416.1 |
| UniProt Related Accession: | Q29416 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-2 |
| NCBI Synonym Full Names: | interleukin 2 |
| NCBI Official Symbol: | IL2�� |
| NCBI Protein Information: | interleukin-2 |
| UniProt Protein Name: | Interleukin-2 |
| UniProt Synonym Protein Names: | T-cell growth factor; TCGF |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL2�� |
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