Canine IFNG Recombinant Protein (RPPB0404)
- SKU:
- RPPB0404
- Product Type:
- Recombinant Protein
- Species:
- Canine
- Uniprot:
- P42161
Description
| Product Name: | Canine IFNG Recombinant Protein |
| Product Code: | RPPB0404 |
| Size: | 20µg |
| Species: | Canine |
| Target: | IFNG |
| Synonyms: | Immune Interferon, type II interferon, T cell interferon, MAF, IFNG, IFG, IFI, IFN-gamma. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The IFNG was lyophilized from a 0.2�m filtered concentrated solution in 25mM Sodium Succinate, pH 5.0, 60mM NaCl, with 0.1% Tween-80. |
| Solubility: | It is recommended to reconstitute the lyophilized IFNG in sterile distilled H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IFNG although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IFNG should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | QAMFFKEIEN LKEYFNASNP DVSDGGSLFV DILKKWREES DKTIIQSQIV SFYLKLFDNF KDNQIIQRSM DTIKEDMLGK FLNSSTSKRE DFLKLIQIPV NDLQVQRKAI NELIKVMNDL SPRSNLRKRK RSQNLFRGRR ASK |
| Biological Activity: | The ED50 as determined by an anti-viral assay using A-72 canine fibroma cells infected with vesicular stomatitis virus (VSV) is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 � 105 IU/mg. |
IFN-gamma produced by lymphocytes activated by specific antigens or mitogens.IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Recombinant IFNG Dog produced in E.coli cells is a non-glycosylated, homodimeric protein containing 143 amino acid chain and having a molecular mass of 16.9kDa. IFNG is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. |
| UniProt Code: | P42161 |
| NCBI GenInfo Identifier: | 12644013 |
| NCBI Gene ID: | 403801 |
| NCBI Accession: | P42161.2 |
| UniProt Secondary Accession: | P42161,Q9TVA0, A1E294, |
| UniProt Related Accession: | P42161 |
| Molecular Weight: | 19,395 Da |
| NCBI Full Name: | Interferon gamma |
| NCBI Synonym Full Names: | interferon gamma |
| NCBI Official Symbol: | IFNG�� |
| NCBI Official Synonym Symbols: | IFN-G; IFN-gamma�� |
| NCBI Protein Information: | interferon gamma |
| UniProt Protein Name: | Interferon gamma |
| Protein Family: | Interferon |
| UniProt Gene Name: | IFNG�� |
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