CAMK2N2 Antibody (PACO63631)
- SKU:
- PACO63631
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CAMK2N2 Antibody (PACO63631) |
| Antibody SKU: | PACO63631 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence from Human Calcium/calmodulin-dependent protein kinase II inhibitor 2 protein (10-28AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of MCF-7 cells with PACO63631 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2. |
| Synonyms: | Calcium/calmodulin-dependent protein kinase II inhibitor 2 (CaM-KII inhibitory protein) (CaM-KIIN), CAMK2N2 |
| UniProt Protein Function: | CAMK2N2: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2. Belongs to the CAMK2N family. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: centrosome; cytosol; nucleus Molecular Function:calcium-dependent protein kinase inhibitor activity; protein kinase binding |
| NCBI Summary: | This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96S95 |
| NCBI GenInfo Identifier: | 15147234 |
| NCBI Gene ID: | 94032 |
| NCBI Accession: | NP_150284.1 |
| UniProt Related Accession: | Q96S95 |
| Molecular Weight: | 8,658 Da |
| NCBI Full Name: | calcium/calmodulin-dependent protein kinase II inhibitor 2 |
| NCBI Synonym Full Names: | calcium/calmodulin dependent protein kinase II inhibitor 2 |
| NCBI Official Symbol: | CAMK2N2 |
| NCBI Official Synonym Symbols: | CAMKIIN; CAM-KIIN |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase II inhibitor 2 |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase II inhibitor 2 |
| UniProt Synonym Protein Names: | CaM-KII inhibitory protein; CaM-KIIN |
| Protein Family: | Calcium/calmodulin-dependent protein kinase II inhibitor |
| UniProt Gene Name: | CAMK2N2 |
| UniProt Entry Name: | CK2N2_HUMAN |
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