CAMK2A Monoclonal Antibody
- SKU:
- CAB22611
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | CAMK2A Monoclonal Antibody |
| Product Code: | CAB22611 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57333 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, U-87MG, Mouse brain, Mouse skeletal muscle, Rat brain |
| Cellular Location: | Cell junction, Presynaptic cell membrane, Synapse |
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 201-300 of human CAMK2A(NP_741960.1). |
| Sequence: | VILYI LLVGY PPFWD EDQHR LYQQI KAGAY DFPSP EWDTV TPEAK DLINK MLTIN PSKRI TAAEA LKHPW ISHRS TVASC MHRQE TVDCL KKFNA RRKLK |
| Synonyms: | CAMKA, MRD53, MRT63, CaMKIIalpha, CaMKIINalpha |
| Calculated MW: | 54kDa |
| Observed MW: | 50kDa |
