Description
Product Name: | CAMK2A Monoclonal Antibody |
Product Code: | CAB22611 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting, Immunohistochemistry |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC57333 |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, IHC-P, ELISA |
Key Applications: | Western blotting, Immunohistochemistry |
Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:500-1:1000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Positive Samples: | 293T, U-87MG, Mouse brain, Mouse skeletal muscle, Rat brain |
Cellular Location: | Cell junction, Presynaptic cell membrane, Synapse |
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene.
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 201-300 of human CAMK2A(NP_741960.1). |
Sequence: | VILYI LLVGY PPFWD EDQHR LYQQI KAGAY DFPSP EWDTV TPEAK DLINK MLTIN PSKRI TAAEA LKHPW ISHRS TVASC MHRQE TVDCL KKFNA RRKLK |
Synonyms: | CAMKA, MRD53, MRT63, CaMKIIalpha, CaMKIINalpha |
Calculated MW: | 54kDa |
Observed MW: | 50kDa |