Description
| Product Name: | Calreticulin Polyclonal Antibody |
| Product Code: | CAB21665 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | HL-60, SH-SY5Y |
| Cellular Location: | Cell surface, Cytoplasm, Endoplasmic reticulum lumen, Sarcoplasmic reticulum lumen, Secreted, cytosol, extracellular matrix, extracellular space |
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-417 of human Calreticulineticulin (NP_004334.1). |
| Sequence: | PAVYF KEQFL DGDGW TSRWI ESKHK SDFGK FVLSS GKFYG DEEKD KGLQT SQDAR FYALS ASFEP FSNKG QTLVV QFTVK HEQNI DCGGG YVKLF PNSLD QTDMH GDSEY NIMFG PDICG PGTKK VHVIF NYKGK NVLIN KDIRC KDDEF THLYT LIVRP DNTYE VKIDN SQVES GSLED DWDFL PPKKI KDPDA SKPED WDERA KIDDP TDSKP EDWDK PEHIP DPDAK KPEDW DEEMD GEWEP PVIQN PEYKG EWKPR QIDNP DYKGT WIHPE IDNPE YSPDP SIYAY DNFGV LGLDL WQVKS GTIFD NFLIT NDEAY AEEFG NETWG VTKAA EKQMK DKQDE EQRLK EEEED KKRKE EEEAE DKEDD EDKDE DEEDE EDKEE DEEED VPGQA KDEL |
| Synonyms: | RO, CRT, SSA, cC1qR, HEL-S-99n |
| Calculated MW: | 47kDa |
| Observed MW: | 55kDa |
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