CALR3 Antibody (PACO43696)
- SKU:
- PACO43696
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CALR3 Antibody (PACO43696) |
| Antibody SKU: | PACO43696 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Calreticulin-3 protein (135-384AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43696 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO43696 at dilution of 1:100. |
| Background: | During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. |
| Synonyms: | Calreticulin-3 (Calreticulin-2) (Calsperin), CALR3, CRT2 |
| UniProt Protein Function: | calreticulin 3: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. CALR3 capacity for calcium- binding may be absent or much lower than that of CALR. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19). CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the calreticulin family.Protein type: Chaperone; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 19p13.11Cellular Component: endoplasmic reticulum lumenMolecular Function: unfolded protein binding; calcium ion binding; carbohydrate bindingBiological Process: protein folding; spermatogenesis; cell differentiationDisease: Cardiomyopathy, Familial Hypertrophic, 19 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q96L12 |
| NCBI GenInfo Identifier: | 116241279 |
| NCBI Gene ID: | 125972 |
| NCBI Accession: | Q96L12.2 |
| UniProt Secondary Accession: | Q96L12,Q96LN3, D9N574 |
| UniProt Related Accession: | Q96L12 |
| Molecular Weight: | |
| NCBI Full Name: | Calreticulin-3 |
| NCBI Synonym Full Names: | calreticulin 3 |
| NCBI Official Symbol: | CALR3 |
| NCBI Official Synonym Symbols: | CRT2; CT93; CMH19 |
| NCBI Protein Information: | calreticulin-3; calreticulin-2; calsperin; cancer/testis antigen 93 |
| UniProt Protein Name: | Calreticulin-3 |
| UniProt Synonym Protein Names: | Calreticulin-2; Calsperin |
| Protein Family: | Calreticulin |
| UniProt Gene Name: | CALR3 |
| UniProt Entry Name: | CALR3_HUMAN |
| Antibodies |
| CALR3 Antibody (PACO08151) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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