CALCA/CALCA Antibody (PACO05367)
- SKU:
- PACO05367
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CALCA/CALCA Antibody (PACO05367) |
| Antibody SKU: | PACO05367 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:10000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the Internal region of human Calcitonin. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CALCA; CALC1; Calcitonin gene-related peptide 1; α-type CGRP; Calcitonin gene-related peptide I; CGRP-I; CALCA; CALC1; Calcitonin |
| UniProt Protein Function: | CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: extracellular region; extracellular space Molecular Function:calcitonin receptor binding; identical protein binding; protein binding Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity |
| NCBI Summary: | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014] |
| UniProt Code: | P06881 |
| NCBI GenInfo Identifier: | 76880478 |
| NCBI Gene ID: | 796 |
| NCBI Accession: | NP_001029125.1 |
| UniProt Secondary Accession: | P06881,Q93048, Q9UCP0, |
| UniProt Related Accession: | P01258,P06881 |
| Molecular Weight: | 15,466 Da |
| NCBI Full Name: | calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein |
| NCBI Synonym Full Names: | calcitonin related polypeptide alpha |
| NCBI Official Symbol: | CALCA |
| NCBI Official Synonym Symbols: | CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I |
| NCBI Protein Information: | calcitonin; calcitonin gene-related peptide 1 |
| UniProt Protein Name: | Calcitonin gene-related peptide 1 |
| UniProt Synonym Protein Names: | Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I |
| Protein Family: | Calcitonin |
| UniProt Gene Name: | CALCA |
| UniProt Entry Name: | CALCA_HUMAN |
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