CACNG8 Antibody (PACO63447)
- SKU:
- PACO63447
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CACNG8 Antibody (PACO63447) |
| Antibody SKU: | PACO63447 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence from Human Voltage-dependent calcium channel gamma-8 subunit protein (65-83AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63447 diluted at 1:700 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. |
| Synonyms: | Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8), CACNG8, CACNG6 |
| UniProt Protein Function: | CACNG8: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calciumChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membrane; postsynaptic densityMolecular Function: channel regulator activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q8WXS5 |
| NCBI GenInfo Identifier: | 313104245 |
| NCBI Gene ID: | 59283 |
| NCBI Accession: | Q8WXS5.3 |
| UniProt Secondary Accession: | Q8WXS5,Q9BXT0, Q9BY23 |
| UniProt Related Accession: | Q8WXS5 |
| Molecular Weight: | 43,313 Da |
| NCBI Full Name: | Voltage-dependent calcium channel gamma-8 subunit |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit gamma 8 |
| NCBI Official Symbol: | CACNG8 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | voltage-dependent calcium channel gamma-8 subunit |
| UniProt Protein Name: | Voltage-dependent calcium channel gamma-8 subunit |
| UniProt Synonym Protein Names: | Neuronal voltage-gated calcium channel gamma-8 subunit; Transmembrane AMPAR regulatory protein gamma-8; TARP gamma-8 |
| Protein Family: | Voltage-dependent calcium channel |
| UniProt Gene Name: | CACNG8 |
| UniProt Entry Name: | CCG8_HUMAN |
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