CABLES2 Antibody (PACO19370)
- SKU:
- PACO19370
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CABLES2 Antibody (PACO19370) |
| Antibody SKU: | PACO19370 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human CABLES2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19370(CABLES2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19370(CABLES2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid, ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene. |
| Synonyms: | Cdk5 and Abl enzyme substrate 2 |
| UniProt Protein Function: | CABLES2: Unknown. Probably involved in G1-S cell cycle transition. Belongs to the cyclin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 20q13.33 |
| UniProt Code: | Q9BTV7 |
| NCBI GenInfo Identifier: | 109940186 |
| NCBI Gene ID: | 81928 |
| NCBI Accession: | Q9BTV7.3 |
| UniProt Secondary Accession: | Q9BTV7,Q5JWL0, Q9BYK0, |
| UniProt Related Accession: | Q9BTV7 |
| Molecular Weight: | 52kDa |
| NCBI Full Name: | CDK5 and ABL1 enzyme substrate 2 |
| NCBI Synonym Full Names: | Cdk5 and Abl enzyme substrate 2 |
| NCBI Official Symbol: | CABLES2 |
| NCBI Official Synonym Symbols: | ik3-2; C20orf150; dJ908M14.2 |
| NCBI Protein Information: | CDK5 and ABL1 enzyme substrate 2 |
| UniProt Protein Name: | CDK5 and ABL1 enzyme substrate 2 |
| UniProt Synonym Protein Names: | Interactor with CDK3 2; Ik3-2 |
| Protein Family: | CDK5 and ABL1 enzyme substrate |
| UniProt Gene Name: | CABLES2 |
| Antibodies |
| CABLES2 Antibody (PACO05433) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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