Description
| Antibody Name: | C5 Antibody (PACO25384) |
| Antibody SKU: | PACO25384 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:10-1:100 |
| Species Reactivity: | Pig |
| Immunogen: | Recombinant Pig Complement C5a anaphylatoxin protein (1-74AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO25384 at dilution of 1:10. |
| Background: | Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). |
| Synonyms: | Complement C5a anaphylatoxin, C5 |
| UniProt Protein Function: | Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P01032 |
| NCBI GenInfo Identifier: | 116605 |
| NCBI Gene ID: | |
| NCBI Accession: | P01032.1 |
| UniProt Secondary Accession: | P01032 |
| UniProt Related Accession: | P01032 |
| Molecular Weight: | 10.6 kDa |
| NCBI Full Name: | Complement C5a anaphylatoxin |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Complement C5a anaphylatoxin |
| UniProt Synonym Protein Names: | |
| Protein Family: | Complement C5 |
| UniProt Gene Name: | C5Â Â |
| UniProt Entry Name: | CO5_PIG |
