C2orf40 Antibody (PACO17812)
- SKU:
- PACO17812
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | C2orf40 Antibody (PACO17812) |
| Antibody SKU: | PACO17812 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human C2orf40 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17812(C2orf40 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17812(C2orf40 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | ECRG4 (esophageal cancer-related gene 4 protein), also known as augurin or C2orf40, is a 148 amino acid, secreted protein. Belonging to the augurin family, ECRG4 is thought to be a hormone. It has also been suggested that ECRG4 may act as a tumor suppressor. The gene that encodes ECRG4 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes, making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr m syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes. |
| Synonyms: | chromosome 2 open reading frame 40 |
| UniProt Protein Function: | C2orf40: Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. Belongs to the augurin family.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 2q12.2Cellular Component: extracellular space; transport vesicleBiological Process: cyclin catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H1Z8 |
| NCBI GenInfo Identifier: | 14165276 |
| NCBI Gene ID: | |
| NCBI Accession: | NP_115787.1 |
| UniProt Secondary Accession: | Q9H1Z8 |
| UniProt Related Accession: | Q9H1Z8 |
| Molecular Weight: | |
| NCBI Full Name: | augurin |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Augurin |
| UniProt Synonym Protein Names: | Esophageal cancer-related gene 4 protein |
| Protein Family: | |
| UniProt Gene Name: | C2orf40 |
| UniProt Entry Name: | AUGN_HUMAN |
| Antibodies |
| C2orf40 Antibody (PACO05519) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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