C2CD3 Antibody (PACO47926)
- SKU:
- PACO47926
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | C2CD3 Antibody (PACO47926) |
| Antibody SKU: | PACO47926 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human C2 domain-containing protein 3 protein (2079-2265AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO47926 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO47926 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO47926 at dilution of 1:100. |
| Background: | Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3. |
| Synonyms: | C2 domain-containing protein 3, C2CD3 |
| UniProt Protein Function: | C2CD3: 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 11q13.4Cellular Component: centriole; centrosome; cytosolMolecular Function: protein bindingBiological Process: neural tube development; sensory cilium biogenesis; in utero embryonic development; neural plate pattern formation; organelle organization and biogenesis; regulation of proteolysis; protein processing; brain development; heart looping; embryonic digit morphogenesis; regulation of smoothened signaling pathwayDisease: Orofaciodigital Syndrome Xiv |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that functions as a regulator of centriole elongation. Studies of the orthologous mouse protein show that it promotes centriolar distal appendage assembly and is also required for the recruitment of other ciliogenic proteins, including intraflagellar transport proteins. Mutations in this gene cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting in malformations of the oral cavity, face and digits. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q4AC94 |
| NCBI GenInfo Identifier: | 148596944 |
| NCBI Gene ID: | 26005 |
| NCBI Accession: | NP_056346.3 |
| UniProt Secondary Accession: | Q4AC94,Q2NLE1, Q3C1U9, Q6ZU92, Q8IYM4, Q8NB87, Q8NDH7 Q9Y4M2, C9JR55, E2QRD1 |
| UniProt Related Accession: | Q4AC94 |
| Molecular Weight: | 213,274 Da |
| NCBI Full Name: | C2 domain-containing protein 3 isoform 2 |
| NCBI Synonym Full Names: | C2 calcium-dependent domain containing 3 |
| NCBI Official Symbol: | C2CD3 |
| NCBI Official Synonym Symbols: | OFD14 |
| NCBI Protein Information: | C2 domain-containing protein 3 |
| UniProt Protein Name: | C2 domain-containing protein 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | C2 domain-containing protein |
| UniProt Gene Name: | C2CD3 |
| UniProt Entry Name: | C2CD3_HUMAN |
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