Description
Antibody Name: | C11orf73 Antibody (PACO08075) |
Antibody SKU: | PACO08075 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human C11orf73 |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | chromosome 11 open reading frame 73;C11orf73;FLJ43020;HSPC138;HSPC179;L7RN6 ; |
UniProt Protein Function: | C11orf73: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. Belongs to the OPI10 family. Following heat-shock treatment. Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats)Protein type: Cell development/differentiationChromosomal Location of Human Ortholog: 11q14.2Cellular Component: cell junction; cytosol; intracellular; nucleoplasm; nucleusMolecular Function: Hsp70 protein binding; protein transporter activityBiological Process: protein import into nucleus; protein transport |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016] |
UniProt Code: | Q53FT3 |
NCBI GenInfo Identifier: | 110278911 |
NCBI Gene ID: | 51501 |
NCBI Accession: | Q53FT3.2 |
UniProt Secondary Accession: | Q53FT3,Q8WVE8, Q9NVQ2, Q9NZZ1, Q9P022, Q9P0N1 |
UniProt Related Accession: | Q53FT3 |
Molecular Weight: | 21,628 Da |
NCBI Full Name: | Protein Hikeshi |
NCBI Synonym Full Names: | Hikeshi, heat shock protein nuclear import factor |
NCBI Official Symbol: | HIKESHI |
NCBI Official Synonym Symbols: | HLD13; L7RN6; OPI10; HSPC138; HSPC179; C11orf73 |
NCBI Protein Information: | protein Hikeshi |
UniProt Protein Name: | Protein Hikeshi |
UniProt Synonym Protein Names: | |
Protein Family: | |
UniProt Gene Name: | C11orf73 |
UniProt Entry Name: | HIKES_HUMAN |