c-Abl Monoclonal Antibody (CAB22199)

(No reviews yet) Write a Review
SKU:
CAB22199
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC

Description

Product Name:c-Abl Monoclonal Antibody
Product Code:CAB22199
Reactivity:Mouse, Rat
Applications:Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC55102
Reactivity:Mouse, Rat
Tested Applications:IHC-P, ELISA
Key Applications:Immunohistochemistry
Recommended Dilution:IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm, Lipid-anchor, Mitochondrion, Nucleus, Nucleus membrane, Cytoskeleton

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1130 of human c-Abl (NP_005148.2).
Sequence:TAFIP LISTR VSLRK TRQPP ERIAS GAITK GVVLD STEAL CLAIS RNSEQ MASHS AVLEA GKNLY TFCVS YVDSI QQMRN KFAFR EAINK LENNL RELQI CPATA GSGPA ATQDF SKLLS SVKEI SDIVQ R
Synonyms:ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1, BCR-ABL, bcr/abl
Calculated MW:123kDa
Observed MW:Refer to figures
View AllClose

0 Reviews

View AllClose

Related Products