Description
Antibody Name: | BRWD1 Antibody (PACO20872) |
Antibody SKU: | PACO20872 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:20-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthetic peptide of human BRWD1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20872(BRWD1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20872(BRWD1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acid, typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex. |
Synonyms: | bromodomain and WD repeat domain containing 1 |
UniProt Protein Function: | May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. |
NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011] |
UniProt Code: | Q9NSI6 |
NCBI GenInfo Identifier: | 313104296 |
NCBI Gene ID: | 54014 |
NCBI Accession: | Q9NSI6.4 |
UniProt Secondary Accession: | Q9NSI6,O43721, Q5R2V0, Q5R2V1, Q6P2D1, Q8TCV3, Q96QG9 Q96QH0, Q9NUK1, C9JK25, |
UniProt Related Accession: | Q9NSI6 |
Molecular Weight: | 263kDa |
NCBI Full Name: | Bromodomain and WD repeat-containing protein 1 |
NCBI Synonym Full Names: | bromodomain and WD repeat domain containing 1 |
NCBI Official Symbol: | BRWD1 |
NCBI Official Synonym Symbols: | N143; WDR9; DCAF19; C21orf107 |
NCBI Protein Information: | bromodomain and WD repeat-containing protein 1 |
UniProt Protein Name: | Bromodomain and WD repeat-containing protein 1 |
UniProt Synonym Protein Names: | WD repeat-containing protein 9 |
Protein Family: | Bromodomain and WD repeat-containing protein |
UniProt Gene Name: | BRWD1 |
Antibodies |
Anti-BRWD1 Antibody (CAB12656) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |