Bovine Leptin Recombinant Protein (RPPB0712)

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SKU:
RPPB0712

Description

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Product Name:Bovine Leptin Recombinant Protein
Product Code:RPPB0712
Size:100µg
Species:Bovine
Target:Leptin
Synonyms:OB Protein, Obesity Protein, OBS, Obesity factor.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
Solubility:It is recommended to reconstitute the lyophilized Leptin in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Leptin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Leptin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Val-Pro-Ile-Arg
Biological Activity:Biological active as evidenced by inducing proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.

A 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores.

Leptin Bovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 146 amino acids and having a molecular mass of 16 kDa.The Leptin is purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P50595
NCBI GenInfo Identifier:87196505
NCBI Gene ID:280836
NCBI Accession:NP_776353.2
UniProt Secondary Accession:P50595,O97918, Q5EAE4, Q95133, Q9TSZ9
UniProt Related Accession:P50595
Molecular Weight:18,716 Da
NCBI Full Name:leptin
NCBI Synonym Full Names:leptin<
NCBI Official Symbol:LEP��
NCBI Official Synonym Symbols:ob��
NCBI Protein Information:leptin; obese; obesity factor; leptin (obesity homolog, mouse)
UniProt Protein Name:Leptin
UniProt Synonym Protein Names:Obesity factor
Protein Family:Leptin
UniProt Gene Name:LEP��
UniProt Entry Name:LEP_BOVIN
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Additional Information

Product Type:
Recombinant Protein
Species:
Bovine
Uniprot:
P50595
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