botB Antibody (PACO34130)
- SKU:
- PACO34130
- Product Type:
- Antibody
- Reactivity:
- Bacteria
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | botB Antibody (PACO34130) |
| Antibody SKU: | PACO34130 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Clostridium botulinum |
| Immunogen: | Recombinant Clostridium botulinum Botulinum neurotoxin type B protein (1-427AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln- |-Phe-77' bond of synaptobrevin-2. |
| Synonyms: | Botulinum neurotoxin type B (BoNT/B) (EC 3.4.24.69) (Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain; Botulinum neurotoxin B heavy chain], botB |
| UniProt Protein Function: | Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P10844 |
| NCBI GenInfo Identifier: | 399134 |
| NCBI Gene ID: | |
| NCBI Accession: | P10844.3 |
| UniProt Secondary Accession: | P10844,P10843 |
| UniProt Related Accession: | P10844 |
| Molecular Weight: | 51.3 kDa |
| NCBI Full Name: | Botulinum neurotoxin type B |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Botulinum neurotoxin type B |
| UniProt Synonym Protein Names: | Bontoxilysin-B |
| Protein Family: | Botulinum neurotoxin |
| UniProt Gene Name: | botB |
| UniProt Entry Name: | BXB_CLOBO |
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