BOD1 Antibody (PACO19358)
- SKU:
- PACO19358
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BOD1 Antibody (PACO19358) |
| Antibody SKU: | PACO19358 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human BOD1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19358(BOD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19358(BOD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects. |
| Synonyms: | biorientation of chromosomes in cell division 1 |
| UniProt Protein Function: | BOD1: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Belongs to the BOD1 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q35.2 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96IK1 |
| NCBI GenInfo Identifier: | 74732069 |
| NCBI Gene ID: | 91272 |
| NCBI Accession: | Q96IK1.2 |
| UniProt Secondary Accession: | Q96IK1,Q9BTW1, B4DXH8 |
| UniProt Related Accession: | Q96IK1 |
| Molecular Weight: | 13,280 Da |
| NCBI Full Name: | Biorientation of chromosomes in cell division protein 1 |
| NCBI Synonym Full Names: | biorientation of chromosomes in cell division 1 |
| NCBI Official Symbol: | BOD1 |
| NCBI Official Synonym Symbols: | FAM44B |
| NCBI Protein Information: | biorientation of chromosomes in cell division protein 1 |
| UniProt Protein Name: | Biorientation of chromosomes in cell division protein 1 |
| UniProt Synonym Protein Names: | Biorientation defective protein 1; Protein FAM44B |
| Protein Family: | Biorientation of chromosomes in cell division protein |
| UniProt Gene Name: | BOD1 |
| UniProt Entry Name: | BOD1_HUMAN |
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