BNP Monoclonal Antibody
- SKU:
- CAB23996
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | BNP Monoclonal Antibody |
| Product Code: | CAB23996 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC62057 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Mouse liver, Mouse heart, Rat heart, Rat brain |
| Cellular Location: | Secreted |
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 35-134 of human BNP (NP_002512.1). |
| Sequence: | ASDLE TSGLQ EQRNH LQGKL SELQV EQTSL EPLQE SPRPT GVWKS REVAT EGIRG HRKMV LYTLR APRSP KMVQG SGCFG RKMDR ISSSS GLGCK VLRRH |
| Synonyms: | BNP, Iso-ANP |
| Calculated MW: | 15kDa |
| Observed MW: | 15kDa |
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