Anti-BMP8A Antibody (PACO23394)

Name: BMP8A Antibody (PACO23394)
SKU: PACO23394
Availability: OutOfStock

Antibody Name:	BMP8A Antibody (PACO23394)
Antibody SKU:	PACO23394
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from C-terminal of human BMP8A.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extracts from COLO cells, using BMP8A antibody.
	Immunofluorescence analysis of A549 cells, using BMP8A antibody.

Background:

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.

Synonyms:

Bone morphogenetic protein 8A [Precursor]; BMP-8A;

UniProt Protein Function:	BMP8A: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Belongs to the TGF-beta family.Protein type: Cytokine; Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 1p34.3Cellular Component: extracellular spaceMolecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor bindingBiological Process: BMP signaling pathway; regulation of apoptosis; ossification; diet induced thermogenesis; regulation of MAPKKK cascade; cartilage development; cell development; growth; negative regulation of insulin secretion
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q7Z5Y6
NCBI GenInfo Identifier:	145611428
NCBI Gene ID:	353500
NCBI Accession:	NP_861525.2
UniProt Secondary Accession:	Q7Z5Y6,Q5T3A5
UniProt Related Accession:	Q7Z5Y6
Molecular Weight:	44,798 Da
NCBI Full Name:	bone morphogenetic protein 8A
NCBI Synonym Full Names:	bone morphogenetic protein 8a
NCBI Official Symbol:	BMP8A
NCBI Official Synonym Symbols:
NCBI Protein Information:	bone morphogenetic protein 8A; BMP-8A
UniProt Protein Name:	Bone morphogenetic protein 8A
UniProt Synonym Protein Names:
Protein Family:	Bone morphogenetic protein
UniProt Gene Name:	BMP8A
UniProt Entry Name:	BMP8A_HUMAN