BLOC1S5 Antibody (PACO38606)
- SKU:
- PACO38606
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BLOC1S5 Antibody (PACO38606) |
| Antibody SKU: | PACO38606 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 5 protein (2-187AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO38606 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO38606 at dilution of 1:100. |
| Background: | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. |
| Synonyms: | Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog), BLOC1S5, MUTED |
| UniProt Protein Function: | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q8TDH9 |
| NCBI GenInfo Identifier: | 313482848 |
| NCBI Gene ID: | 63915 |
| NCBI Accession: | NP_001186251.1 |
| UniProt Secondary Accession: | Q8TDH9,Q0VDJ6, Q0VDJ7, Q5THS1, Q68D56, Q8N5F9, Q9NU16 B4DVM2 |
| UniProt Related Accession: | Q8TDH9 |
| Molecular Weight: | 14,893 Da |
| NCBI Full Name: | biogenesis of lysosome-related organelles complex 1 subunit 5 isoform 2 |
| NCBI Synonym Full Names: | biogenesis of lysosomal organelles complex 1 subunit 5 |
| NCBI Official Symbol: | BLOC1S5 |
| NCBI Official Synonym Symbols: | MU; BLOS5; MUTED |
| NCBI Protein Information: | biogenesis of lysosome-related organelles complex 1 subunit 5 |
| UniProt Protein Name: | Biogenesis of lysosome-related organelles complex 1 subunit 5 |
| UniProt Synonym Protein Names: | Protein Muted homolog |
| Protein Family: | |
| UniProt Gene Name: | BLOC1S5 |
| UniProt Entry Name: |
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