BHLHE23 Antibody (PACO64163)
- SKU:
- PACO64163
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BHLHE23 Antibody (PACO64163) |
| Antibody SKU: | PACO64163 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:100-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Class E basic helix-loop-helix protein 23 protein (1-225AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO64163 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| Background: | May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity). |
| Synonyms: | Class E basic helix-loop-helix protein 23 (bHLHe23) (Class B basic helix-loop-helix protein 4) (bHLHb4), BHLHE23, BHLHB4 |
| UniProt Protein Function: | BHLHE23: May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation.Protein type: Transcription factorChromosomal Location of Human Ortholog: 20q13.33Cellular Component: nucleusMolecular Function: protein dimerization activity; DNA bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013] |
| UniProt Code: | Q8NDY6 |
| NCBI GenInfo Identifier: | 506326971 |
| NCBI Gene ID: | 128408 |
| NCBI Accession: | NP_542173.2 |
| UniProt Secondary Accession: | Q8NDY6,B2RP69 |
| UniProt Related Accession: | Q8NDY6 |
| Molecular Weight: | 23,665 Da |
| NCBI Full Name: | class E basic helix-loop-helix protein 23 |
| NCBI Synonym Full Names: | basic helix-loop-helix family, member e23 |
| NCBI Official Symbol: | BHLHE23 |
| NCBI Official Synonym Symbols: | BETA4; BHLHB4; bA305P22.3 |
| NCBI Protein Information: | class E basic helix-loop-helix protein 23; class B basic helix-loop-helix protein 4; basic helix-loop-helix domain containing, class B, 4 |
| UniProt Protein Name: | Class E basic helix-loop-helix protein 23 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 4; bHLHb4 |
| Protein Family: | Class E basic helix-loop-helix protein |
| UniProt Gene Name: | BHLHE23 |
| UniProt Entry Name: | BHE23_HUMAN |
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