BHLHA15 Antibody (PACO61033)
- SKU:
- PACO61033
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BHLHA15 Antibody (PACO61033) |
| Antibody SKU: | PACO61033 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Class A basic helix-loop-helix protein 15 protein (2-72AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61033 diluted at 1:150 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity). |
| Synonyms: | Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1), BHLHA15, BHLHB8 MIST1 |
| UniProt Protein Function: | MIST1: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3'.Chromosomal Location of Human Ortholog: 7q21.3Cellular Component: nucleusMolecular Function: protein homodimerization activityBiological Process: G-protein coupled receptor protein signaling pathway; cellular response to glucose starvation; transcription, DNA-dependent; cell-cell signaling; unfolded protein response; cell maturation; intracellular distribution of mitochondria; calcium-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; glucose homeostasis; Golgi organization and biogenesis; mitochondrial calcium ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7RTS1 |
| NCBI GenInfo Identifier: | 29126247 |
| NCBI Gene ID: | 168620 |
| NCBI Accession: | NP_803238.1 |
| UniProt Secondary Accession: | Q7RTS1,Q14DE4, A4D271 |
| UniProt Related Accession: | Q7RTS1 |
| Molecular Weight: | 20,818 Da |
| NCBI Full Name: | class A basic helix-loop-helix protein 15 |
| NCBI Synonym Full Names: | basic helix-loop-helix family, member a15 |
| NCBI Official Symbol: | BHLHA15 |
| NCBI Official Synonym Symbols: | MIST1; BHLHB8 |
| NCBI Protein Information: | class A basic helix-loop-helix protein 15; MIST-1; class II bHLH protein MIST1; class B basic helix-loop-helix protein 8; muscle, intestine and stomach expression 1; basic helix-loop-helix domain containing, class B, 8 |
| UniProt Protein Name: | Class A basic helix-loop-helix protein 15 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 8; bHLHb8; Muscle, intestine and stomach expression 1; MIST-1 |
| Protein Family: | Class A basic helix-loop-helix protein |
| UniProt Gene Name: | BHLHA15 |
| UniProt Entry Name: | BHA15_HUMAN |
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