BEST3 Antibody (PACO08005)
- SKU:
- PACO08005
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BEST3 Antibody (PACO08005) |
| Antibody SKU: | PACO08005 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Human BEST3 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | bestrophin 3;BEST3;MGC13168;MGC40411;VMD2L3 ; |
| UniProt Protein Function: | VMD2L3: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Belongs to the bestrophin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integralChromosomal Location of Human Ortholog: 12q15Cellular Component: integral to plasma membraneMolecular Function: chloride channel activityBiological Process: negative regulation of ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8N1M1 |
| NCBI GenInfo Identifier: | 38503351 |
| NCBI Gene ID: | 144453 |
| NCBI Accession: | Q8N1M1.1 |
| UniProt Secondary Accession: | Q8N1M1,Q53YQ7, Q8N356, Q8NFT9, Q9BR80, B5MDI8, F8VVZ2 |
| UniProt Related Accession: | Q8N1M1 |
| Molecular Weight: | 63,378 Da |
| NCBI Full Name: | Bestrophin-3 |
| NCBI Synonym Full Names: | bestrophin 3 |
| NCBI Official Symbol: | BEST3 |
| NCBI Official Synonym Symbols: | VMD2L3 |
| NCBI Protein Information: | bestrophin-3 |
| UniProt Protein Name: | Bestrophin-3 |
| UniProt Synonym Protein Names: | Vitelliform macular dystrophy 2-like protein 3 |
| Protein Family: | Bestrophin |
| UniProt Gene Name: | BEST3 |
| UniProt Entry Name: | BEST3_HUMAN |
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