Beclin 1 Monoclonal Antibody (CAB22359)
- SKU:
- CAB22359
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Beclin 1 Monoclonal Antibody |
| Product Code: | CAB22359 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52867 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:10000-1:30000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, HeLa, Jurkat, Mouse testis, Rat lung |
Beclin 1 plays a central role in autophagy. It acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis.There two casp cleavage sites in Beclin 1, TDVD(133) and DQLD(149), cleavage at which yields fragments lacking the autophagy-inducing capacity. Noteworthy, the C-terminal fragment, Beclin 1-C, localized predominantly at the mitochondria and sensitized the cells to apoptosis. It induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Beclin 1 (NP_003757.1). |
| Sequence: | MEGSK TSNNS TMQVS FVCQR CSQPL KLDTS FKILD RVTIQ ELTAP LLTTA QAKPG ETQEE ETNSG EEPFI ETPRQ DGVSR RFIPP ARMMS TESAN SFTLI GEASD GGTME NLSRR LKVTG DLFDI MSGQT DVDHP LCEEC TDTLL DQLDT QLNVT ENECQ NYKRC LEILE QMNED DSEQL QMELK ELALE EERLI QELED VEKNR KIVAE NLEKV QAEAE RLDQE EAQYQ REYSE FKRQQ LELDD ELKSV ENQMR YAQTQ LDKLK KTNVF NATFH IWHSG |
| Observed MW: | 60kDa |
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