BCOR Antibody (PACO37098)
- SKU:
- PACO37098
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BCOR Antibody (PACO37098) |
| Antibody SKU: | PACO37098 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human BCL-6 corepressor protein (1569-1755AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). |
| Synonyms: | BCL-6 corepressor (BCoR), BCOR, KIAA1575 |
| UniProt Protein Function: | BCOR: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Belongs to the BCOR family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: mitochondrion; nucleus; PcG protein complex Molecular Function:heat shock protein binding; histone deacetylase binding; protein binding; transcription corepressor activity; transcription factor binding; ubiquitin-protein ligase activity Biological Process: heart development; negative regulation of bone mineralization; negative regulation of histone H3-K36 methylation; negative regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis; palate development; specification of axis polarity Disease: Microphthalmia, Syndromic 1; Microphthalmia, Syndromic 2 |
| NCBI Summary: | The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q6W2J9 |
| NCBI GenInfo Identifier: | 57012588 |
| NCBI Gene ID: | 54880 |
| NCBI Accession: | Q6W2J9.1 |
| UniProt Secondary Accession: | Q6W2J9,Q29RF6, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232 Q9H233, Q9HCJ7, Q9NXF2, D3DWB3, D3DWB4, |
| UniProt Related Accession: | Q6W2J9 |
| Molecular Weight: | 186,235 Da |
| NCBI Full Name: | BCL-6 corepressor |
| NCBI Synonym Full Names: | BCL6 corepressor |
| NCBI Official Symbol: | BCOR |
| NCBI Official Synonym Symbols: | MAA2; ANOP2; MCOPS2 |
| NCBI Protein Information: | BCL-6 corepressor |
| UniProt Protein Name: | BCL-6 corepressor |
| Protein Family: | BCL-6 corepressor |
| UniProt Gene Name: | BCOR |
| UniProt Entry Name: | BCOR_HUMAN |
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