BCL6 Monoclonal Antibody
- SKU:
- CAB22610
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | BCL6 Monoclonal Antibody |
| Product Code: | CAB22610 |
| Reactivity: | Human |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57886 |
| Reactivity: | Human |
| Tested Applications: | IHC-P, FC, FC(Intra), ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:500-1:1000, FC 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-350 of human BCL6(NP_001124317.1). |
| Sequence: | PKERA LPCDS ARPVP GEYSR PTLEV SPNVC HSNIY SPKET IPEEA RSDMH YSVAE GLKPA APSAR NAPYF PCDKA SKEEE RPSSE DEIAL HFEPP NAPLN RKGLV SPQSP QKSDC QPNSP TESCS SKNAC ILQAS G |
| Synonyms: | BCL5, LAZ3, BCL6A, ZNF51, ZBTB27 |
| Calculated MW: | 79kDa |
| Observed MW: | Refer to figures |
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