Bcl10 Polyclonal Antibody

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SKU:
CAB0191
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:Bcl10 Polyclonal Antibody
Product Code:CAB0191
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Mouse ovary
Cellular Location:Cytoplasm, Membrane raft, perinuclear region

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human Bcl10 (NP_003912.1).
Sequence:MEPTA PSLTE EDLTE VKKDA LENLR VYLCE KIIAE RHFDH LRAKK ILSRE DTEEI SCRTS SRKRA GKLLD YLQEN PKGLD TLVES IRREK TQNFL IQKIT DEVLK LRNIK LEHLK GLK
Synonyms:CLAP, mE10, CIPER, IMD37, c-E10, CARMEN
Calculated MW:26kDa
Observed MW:32kDa
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