Bcl-2 Polyclonal Antibody (CAB2845)

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SKU:
CAB2845
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF
Applications:
IP

Description

Product Name:Bcl-2 Polyclonal Antibody
Product Code:CAB2845
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence, Immunoprecipitation
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, IP, ELISA
Key Applications:Western blotting, Immunofluorescence, Immunoprecipitation
Recommended Dilution:WB 1:500-1:1000, IF/ICC 1:50-1:100, IP 1:50-1:100
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:Jurkat, Mouse lung
Cellular Location:Endoplasmic reticulum membrane, Mitochondrion outer membrane, Nucleus membrane, Single-pass membrane protein
Customer Validation:WB(Human tumor cell, Rattus norvegicus, Mus musculus, Homo sapiens, African green monkey )

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-239 of human Bcl-2 (NP_000624.2).
Sequence:MAHAG RTGYD NREIV MKYIH YKLSQ RGYEW DAGDV GAAPP GAAPA PGIFS SQPGH TPHPA ASRDP VARTS PLQTP AAPGA AAGPA LSPVP PVVHL TLRQA GDDFS RRYRR DFAEM SSQLH LTPFT ARGRF ATVVE ELFRD GVNWG RIVAF FEFGG VMCVE SVNRE MSPLV DNIAL WMTEY LNRHL HTWIQ DNGGW DAFVE LYGPS MRPLF DFSWL SLKTL LSLAL VGACI TLGAY LGHK
Synonyms:Bcl-2, PPP1R50
Calculated MW:26kDa
Observed MW:26kDa
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