BCAS4 Antibody (PACO19345)
- SKU:
- PACO19345
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BCAS4 Antibody (PACO19345) |
| Antibody SKU: | PACO19345 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:15-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human BCAS4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19345(BCAS4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The gene encoding BCAS4 (Breast carcinoma-amplified sequence 4), a 211 amino acid, protein, is found in a region on chromosome 20 that is frequently amplified in human breast cancer. This 20q13 locus amplification is found in 12%39% of primary breast tumors, which correlates with a 17q23 locus amplification that is found in 20% of primary breast tumors. The amplification and translocation between the BCAS4 gene and the BCAS3 gene, with a 17q23 locus, results in a fusion transcript that is overexpressed in MCF-7 cells. Also, deletion of chromosomal region 20q13.13-q13.2 and resultant deletion of BCAS4, as well as three other genes, is the cause of Okihiro syndrome, a disease characterized by ocular and upper limb anomalies. BCAS4 is normally expressed in thymus, kidney, spleen, placenta and brain. There are three isoforms of BCAS4 which are produced as a result of alternative splicing events. |
| Synonyms: | breast carcinoma amplified sequence 4 |
| UniProt Protein Function: | BCAS4: A chromosomal aberration involving BCAS4 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS3. Belongs to the cappuccino family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 20q13.13Biological Process: intracellular transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8TDM0 |
| NCBI GenInfo Identifier: | 33301030 |
| NCBI Gene ID: | 55653 |
| NCBI Accession: | Q8TDM0.1 |
| UniProt Secondary Accession: | Q8TDM0,Q5TD52, Q5TD53, Q5TD54, Q5U5K7, Q5XKE8, Q8IXI7 Q8NEZ6, Q8TDL9, Q9NX13 |
| UniProt Related Accession: | Q8TDM0 |
| Molecular Weight: | 22,495 Da |
| NCBI Full Name: | Breast carcinoma-amplified sequence 4 |
| NCBI Synonym Full Names: | breast carcinoma amplified sequence 4 |
| NCBI Official Symbol: | BCAS4 |
| NCBI Official Synonym Symbols: | CNOL |
| NCBI Protein Information: | breast carcinoma-amplified sequence 4 |
| UniProt Protein Name: | Breast carcinoma-amplified sequence 4 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Breast carcinoma-amplified sequence |
| UniProt Gene Name: | BCAS4 |
| UniProt Entry Name: | BCAS4_HUMAN |
| Antibodies |
| BCAS4 Antibody (PACO04705) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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