Description
Antibody Name: | BBC3 Antibody |
Antibody SKU: | PACO01380 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | synthesized peptide derived from the C-terminal region of human PUMA. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis |
UniProt Protein Function: | PUMA: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol Molecular Function:protein binding Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; determination of adult life span; response to DNA damage stimulus; negative regulation of growth |
NCBI Summary: | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9BXH1 |
NCBI GenInfo Identifier: | 56748610 |
NCBI Gene ID: | 27113 |
NCBI Accession: | Q9BXH1.1 |
UniProt Secondary Accession: | Q9BXH1,O00171, Q96PG9, B9EGI3, |
UniProt Related Accession: | Q96PG8,Q9BXH1 |
Molecular Weight: | 193 |
NCBI Full Name: | Bcl-2-binding component 3 |
NCBI Synonym Full Names: | BCL2 binding component 3 |
NCBI Official Symbol: | BBC3 |
NCBI Official Synonym Symbols: | JFY1; PUMA; JFY-1 |
NCBI Protein Information: | bcl-2-binding component 3; p53 up-regulated modulator of apoptosis |
UniProt Protein Name: | Bcl-2-binding component 3 |
UniProt Synonym Protein Names: | JFY-1; p53 up-regulated modulator of apoptosis |
Protein Family: | Bcl-2-binding component |
UniProt Gene Name: | BBC3 |
UniProt Entry Name: | BBC3_HUMAN |