Batf3 Antibody (PACO25212)
- SKU:
- PACO25212
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Batf3 Antibody (PACO25212) |
| Antibody SKU: | PACO25212 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Basic leucine zipper transcriptional factor ATF-like 3 protein (1-133AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | AP-1 family transcription factor that controls the differentiation of CD8+ thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha+ classical dendritic cells (cDCs) and related CD103+ dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). |
| Synonyms: | Basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3) (Jun dimerization protein 1) (JDP-1), Batf3, Jdp1 |
| UniProt Protein Function: | BATF3: Functions as a negative regulator of AP-1-mediated transcription by heterodimerizing with JUN and binding DNA at 12- O-tetradecanoylphorbol-13-acetate response elements (TRE) (consensus: 5'-TGA[CG]TCA-3'). Represses IL2 and MMP1 promoter activities. Belongs to the bZIP family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 1q32.3Cellular Component: nucleusMolecular Function: protein binding; transcription corepressor activity; transcription factor activityBiological Process: myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; response to virus; transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009] |
| UniProt Code: | P97876 |
| NCBI GenInfo Identifier: | 74752916 |
| NCBI Gene ID: | 55509 |
| NCBI Accession: | Q9NR55.1 |
| UniProt Secondary Accession: | P97876,Q9D275, P97876 |
| UniProt Related Accession: | P97876,Q9NR55 |
| Molecular Weight: | 14,468 Da |
| NCBI Full Name: | Basic leucine zipper transcriptional factor ATF-like 3 |
| NCBI Synonym Full Names: | basic leucine zipper ATF-like transcription factor 3 |
| NCBI Official Symbol: | BATF3 |
| NCBI Official Synonym Symbols: | JDP1; SNFT; JUNDM1 |
| NCBI Protein Information: | basic leucine zipper transcriptional factor ATF-like 3 |
| UniProt Protein Name: | Basic leucine zipper transcriptional factor ATF-like 3 |
| UniProt Synonym Protein Names: | 21 kDa small nuclear factor isolated from T-cells; Jun dimerization protein p21SNFT |
| Protein Family: | Basic leucine zipper transcriptional factor |
| UniProt Gene Name: | BATF3 |
| UniProt Entry Name: | BATF3_HUMAN |
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