BATF2 Antibody (PACO38226)
- SKU:
- PACO38226
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BATF2 Antibody (PACO38226) |
| Antibody SKU: | PACO38226 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Basic leucine zipper transcriptional factor ATF-like 2 protein (1-189AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO38226 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO38226 at dilution of 1:100. |
| Background: | AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter. |
| Synonyms: | Basic leucine zipper transcriptional factor ATF-like 2 (B-ATF-2) (Suppressor of AP-1 regulated by IFN) (SARI), BATF2 |
| UniProt Protein Function: | BATF2: Belongs to the bZIP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 11q13.1Cellular Component: nucleusMolecular Function: protein bindingBiological Process: defense response to protozoan; myeloid dendritic cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N1L9 |
| NCBI GenInfo Identifier: | 74750901 |
| NCBI Gene ID: | 116071 |
| NCBI Accession: | Q8N1L9.1 |
| UniProt Secondary Accession: | Q8N1L9,Q8NAF4, Q8NAL8, Q96EH4, D9IC56 |
| UniProt Related Accession: | Q8N1L9 |
| Molecular Weight: | 19,503 Da |
| NCBI Full Name: | Basic leucine zipper transcriptional factor ATF-like 2 |
| NCBI Synonym Full Names: | basic leucine zipper ATF-like transcription factor 2 |
| NCBI Official Symbol: | BATF2 |
| NCBI Official Synonym Symbols: | SARI |
| NCBI Protein Information: | basic leucine zipper transcriptional factor ATF-like 2 |
| UniProt Protein Name: | Basic leucine zipper transcriptional factor ATF-like 2 |
| UniProt Synonym Protein Names: | Suppressor of AP-1 regulated by IFN; SARI |
| Protein Family: | Basic leucine zipper transcriptional factor |
| UniProt Gene Name: | BATF2 |
| UniProt Entry Name: | BATF2_HUMAN |
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