BARD1 Antibody (PACO00455)
- SKU:
- PACO00455
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BARD1 Antibody |
| Antibody SKU: | PACO00455 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the N-terminal region of human BARD1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | BARD1; BRCA1-associated RING domain protein 1; BARD-1 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q99728 |
| NCBI GenInfo Identifier: | 116241265 |
| NCBI Gene ID: | 580 |
| NCBI Accession: | Q99728.2 |
| UniProt Secondary Accession: | Q99728 |
| UniProt Related Accession: | Q99728 |
| Molecular Weight: | 74kDa |
| NCBI Full Name: | BRCA1-associated RING domain protein 1 |
| NCBI Synonym Full Names: | BRCA1 associated RING domain 1 |
| NCBI Official Symbol: | BARD1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | BRCA1-associated RING domain protein 1 |
| UniProt Protein Name: | |
| UniProt Synonym Protein Names: | |
| Protein Family: | BRCA1-associated RING domain protein |
| UniProt Gene Name: | |
| UniProt Entry Name: |
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