BACH2 Antibody (PACO60392)
- SKU:
- PACO60392
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | BACH2 Antibody (PACO60392) |
| Antibody SKU: | PACO60392 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Transcription regulator protein BACH2 protein (136-235AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO60392 diluted at 1:200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Immunofluorescence staining of SH-SY5Y cells with PACO60392 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). |
| Synonyms: | Transcription regulator protein BACH2 (BTB and CNC homolog 2), BACH2 |
| UniProt Protein Function: | BACH2: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK. Belongs to the bZIP family. CNC subfamily.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 6q15Cellular Component: nucleusMolecular Function: transcription factor activity; ubiquitin-protein ligase activityBiological Process: transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BYV9 |
| NCBI GenInfo Identifier: | 17433037 |
| NCBI Gene ID: | 60468 |
| NCBI Accession: | Q9BYV9.1 |
| UniProt Secondary Accession: | Q9BYV9,Q59H70, Q5T793, Q9NTS5, E1P518 |
| UniProt Related Accession: | Q9BYV9 |
| Molecular Weight: | 92,537 Da |
| NCBI Full Name: | Transcription regulator protein BACH2 |
| NCBI Synonym Full Names: | BTB domain and CNC homolog 2 |
| NCBI Official Symbol: | BACH2 |
| NCBI Official Synonym Symbols: | BTBD25 |
| NCBI Protein Information: | transcription regulator protein BACH2 |
| UniProt Protein Name: | Transcription regulator protein BACH2 |
| UniProt Synonym Protein Names: | BTB and CNC homolog 2 |
| Protein Family: | Transcription regulator protein |
| UniProt Gene Name: | BACH2 |
| UniProt Entry Name: | BACH2_HUMAN |
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